Role of Kupffer cells in the release of nitric oxide and change of portal pressure after ethanol perfusion in the rat liver.
Alcohol Alcohol
; 35(1): 31-4, 2000 Jan.
Article
em En
| MEDLINE
| ID: mdl-10684773
ABSTRACT
The objective of this study was to elucidate the role of Kupffer cells during the increase of portal vein pressure caused by ethanol. We measured nitric oxide (NO) in the perfused rat liver using a commercial NO meter. Ethanol perfusion increased NO release and portal vein pressure. Gadolinium chloride pretreatment reduced the increase in portal vein pressure during the early phase of ethanol perfusion, but did not affect the release of NO after ethanol infusion. These findings suggest that Kupffer cells play an important role in liver microcirculation during the early stage of ethanol intake, but that the mechanism may not be regulated by NO.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Depressores do Sistema Nervoso Central
/
Pressão na Veia Porta
/
Etanol
/
Células de Kupffer
/
Fígado
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
Alcohol Alcohol
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Japão