TMC-171A,B,C and TMC-154, novel polyketide antibiotics produced by Gliocladium sp. TC 1304 and TC 1282.
J Antibiot (Tokyo)
; 52(12): 1114-23, 1999 Dec.
Article
em En
| MEDLINE
| ID: mdl-10695675
ABSTRACT
Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fungos Mitospóricos
/
Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Japão