No evidence of correlation between mutation at codon 531 of src and the risk of colon cancer in Chinese.
Cancer Lett
; 150(2): 201-4, 2000 Mar 31.
Article
em En
| MEDLINE
| ID: mdl-10704743
ABSTRACT
The protein tyrosine kinase activity of c-src proto-oncogene product, pp60(c-src), is elevated in a number of human cancers, including colon cancer. Phosphorylation of human pp60(c-src) carboxy-terminal tyrosine 530 suppresses its kinase activity. A recent report suggested that the risk of colon cancer is higher for those who carry a C-->T transition mutation on codon 531 (Gln-531-->Amber-531) of src gene. This mutation caused a prematured translation termination and up-regulated the kinase activity. To examine whether this mutation could be a risk factor for colon carcinoma in the Chinese population, we used the same PCR-based assay to analyze src genotypes of 131 colon cancers and other various types of carcinoma. No mutation was detected in all specimens that were screened in this study. Thus, mutation at Gln-531 of src gene does not seem to be involved in the development of colon cancer in Chinese ethnicity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Códon
/
Genes src
/
Neoplasias do Colo
/
Mutação
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Taiwan