Candidate taste receptors in Drosophila.
Science
; 287(5459): 1830-4, 2000 Mar 10.
Article
em En
| MEDLINE
| ID: mdl-10710312
ABSTRACT
Little is known about the molecular mechanisms of taste perception in animals, particularly the initial events of taste signaling. A large and diverse family of seven transmembrane domain proteins was identified from the Drosophila genome database with a computer algorithm that identifies proteins on the basis of structure. Eighteen of 19 genes examined were expressed in the Drosophila labellum, a gustatory organ of the proboscis. Expression was not detected in a variety of other tissues. The genes were not expressed in the labellum of a Drosophila mutant, pox-neuro70, in which taste neurons are eliminated. Tissue specificity of expression of these genes, along with their structural similarity, supports the possibility that the family encodes a large and divergent family of taste receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Quimiorreceptoras
/
Receptores de Superfície Celular
/
Proteínas de Insetos
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Proteínas de Drosophila
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Drosophila melanogaster
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Proteínas de Membrana
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Neurônios Aferentes
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos