T cells can use either T cell receptor or CD28 receptors to absorb and internalize cell surface molecules derived from antigen-presenting cells.
J Exp Med
; 191(7): 1137-48, 2000 Apr 03.
Article
em En
| MEDLINE
| ID: mdl-10748232
ABSTRACT
At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)-peptide-major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function-associated antigen 1 (LFA-1) on T cells interacting with B7 (B7-1 and B7-2), and intracellular adhesion molecule 1 (ICAM-1), respectively, on APCs. Here, we show that during T cell-APC interaction, T cells rapidly absorb various molecules from APCs onto the cell membrane and then internalize these molecules. This process is dictated by at least two receptors on T cells, namely CD28 and TCR molecules. The biological significance of T cell uptake of molecules from APCs is unclear. One possibility is that this process may allow activated T cells to move freely from one APC to another and eventually gain entry into the circulation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Receptores de Antígenos de Linfócitos T
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Linfócitos T
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Antígenos CD
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Antígeno B7-1
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Antígenos CD28
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Molécula 1 de Adesão Intercelular
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Células Apresentadoras de Antígenos
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos