Perceptual auditory gap detection deficits in male BXSB mice with cerebrocortical ectopias.
Neuroreport
; 11(4): 693-6, 2000 Mar 20.
Article
em En
| MEDLINE
| ID: mdl-10757502
ABSTRACT
Underlying impairments in rapid auditory processing may contribute to disrupted phonological processing, which in turn characterizes developmental language impairment (LI). Identification of a neurobiological feature of LI that is associated with auditory deficits would further support this model. Accordingly, we found that adult male rats with induced cortical malformations were impaired in rapid auditory processing. Since 40-60% of BXSB mice exhibit spontaneous focal cerebrocortical ectopias (as seen in dyslexics brains), we assessed auditory gap detection in adult male BXSB mice. Ectopic mice were significantly worse than non-ectopics in detecting a 5 ms silent gap, but were not significantly impaired at longer gap durations (10-100 ms). Our results confirm that focal cortical malformations are associated with impairments in rapid auditory processing.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vias Auditivas
/
Percepção Auditiva
/
Transtornos da Percepção Auditiva
/
Córtex Cerebral
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos