Ursodeoxycholic acid therapy in hepatobiliary disease.
Am J Med
; 108(6): 481-6, 2000 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-10781781
ABSTRACT
Ursodeoxycholic acid is a hydrophilic bile acid that under normal circumstances represents a small fraction of the bile acid pool in humans. It is effective in dissolving cholesterol gallstones in appropriately selected patients. Ursodeoxycholic acid improves serum alkaline phosphatase and aminotransferase levels in primary biliary cirrhosis, but its effects on rates of liver transplantation and death are less certain. Ursodeoxycholic acid has had promising [corrected] effects in several other cholestatic liver diseases, such as cystic fibrosis and intrahepatic cholestasis of pregnancy, but data are too preliminary to make recommendations about its routine use in these conditions. Its effects are mediated by amelioration of damage to cell membranes caused by retained toxic bile acids. Ursodeoxycholic acid improves biliary secretion of bile acids, may improve bile flow, and it has immunomodulatory properties that may reduce immune-mediated liver damage. However, its use in the treatment of cholestatic liver disease remains uncertain pending additional randomized trials.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ursodesoxicólico
/
Doenças Biliares
/
Colagogos e Coleréticos
/
Colestase
/
Hepatopatias
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Guideline
Limite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Am J Med
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos