Pain mechanisms and management: a central perspective.
Clin J Pain
; 16(3 Suppl): S144-56, 2000 Sep.
Article
em En
| MEDLINE
| ID: mdl-11014459
ABSTRACT
Although pain is always intense and unpleasant, the capacity to experience this sensation is, under normal circumstances, fundamental to the preservation of bodily integrity. Clinically, however, after injury to peripheral tissue or directly to the nervous system, spontaneous and evoked pain manifest that serve no physiologic function, are crippling to patients, and are difficult to treat. Here, we review the specific role of the dorsal horn of the spinal cord in the mechanisms of nociceptive protective pain and the spinal plasticity that occurs after nerve and tissue injury. This spinal neuronal plasticity is shown to be a key contributor to pathologic pain hypersensitivity. The potential for the molecular mechanisms responsible for the spinal plasticity in revealing new targets for future treatment is also discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Cuidados Paliativos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Clin J Pain
Assunto da revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos