Successful immunosuppressant therapy of severe progressive cerebellar degeneration and sensory neuropathy: a case report.
J Neurol Sci
; 178(1): 63-5, 2000 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-11018251
ABSTRACT
A 56 year old woman had a 19 month history of a severe subacute progressive cerebellar degeneration, peripheral sensory neuropathy, and urinary incontinence. She was confined to a wheelchair, needed assistance with eating, and her speech was almost unintelligible. No underlying cancer was found despite repeated investigations, and no autoantibodies were demonstrated. She received a 3-month course of intensive immunosuppressant therapy with intravenous immunoglobulin 400 mg/kg per day for 5 days every month, oral cyclophosphamide 50 mg twice or three times a day to maintain the total lymphocyte count between 500 and 750/mm(3), and prednisone 60 mg per day. She experienced dramatic subjective and objective improvement. The dysarthria and the upper extremity dysmetria disappeared, and she regained the ability to write and cook. The lower extremity ataxia improved and she became able to walk with a cane. Urinary incontinence disappeared. A trial of intensive immunosuppressant treatment is worth considering in a patient with a clinical syndrome resembling paraneoplastic disorders, even if an underlying neoplasm and autoantibodies are not demonstrated.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Incontinência Urinária
/
Degeneração Paraneoplásica Cerebelar
/
Polineuropatia Paraneoplásica
/
Imunossupressores
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos