Gene aberrations in childhood brain tumors.
Folia Biol (Praha)
; 46(5): 187-90, 2000.
Article
em En
| MEDLINE
| ID: mdl-11055797
ABSTRACT
We present the results of the examination of prognostic markers in 40 children suffering from brain tumors. Prognostic markers such as amplification of the N-myc and c-myc, deletion of the 17p, and DNA ploidy are indispensable factors for the determination of diagnosis. An increased number of c-myc gene copies was found in malignant brain tumors, especially embryonal, more often than reported in the literature. N-myc amplification occurs in our group seldom, but it seems to be a sign of worse prognosis in glial and embryonal brain tumors. DNA aneuploidy was not found very frequently, but in high-grade tumors only.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Aberrações Cromossômicas
/
Aneuploidia
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Folia Biol (Praha)
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
República Tcheca