Influence of vitamin C supplementation on cytokine changes following an ultramarathon.
J Interferon Cytokine Res
; 20(11): 1029-35, 2000 Nov.
Article
em En
| MEDLINE
| ID: mdl-11096461
ABSTRACT
The influence of vitamin C supplementation on the pattern of change in plasma cytokine concentrations was measured in 29 runners following a 90-km ultramarathon. The study was based on a 3 (groups) by 4 (blood samples at 16 prerace, postrace, and 24 h and 48 h postrace) repeated measures design. Groups included placebo control (n = 7) and two groups supplementing vitamin C at 500 mg/day (vit C-500, n = 10) or 1500 mg/day (vit C-1500, n = 12) for 7 days before the race, on race day, and for 2 days after the race. All measured plasma cytokine concentrations were significantly elevated immediately postrace, with the magnitude of increase for tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) much smaller than for IL-6, IL-10, IL-8, and IL-1 receptor antagonist (IL-1RA). Cortisol increased in all groups immediately after the race but significantly less in the vit C-1500 group. Group x time interaction statistics were not significant for any of the plasma cytokines. However, when the placebo and vit C-500 groups were combined (n = 17) and compared with the vit C-1500 group (n = 12), immediate postrace plasma concentrations were significantly lower in the vit C-1500 group for IL-1RA (-57%) and IL-10 (-57%), with a trend measured for IL-6 (-27%, p = 0.11) and IL-8 (-26%, p = 0.14). In summary, runners completing the 90-km Comrades Ultramarathon experienced strong increases in concentrations of plasma IL-6, IL-10, IL-1RA, and IL-8. These increases were attenuated in runners ingesting 1500 mg but not 500 mg vitamin C supplements for 1 week prior to the race and on race day.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Ascórbico
/
Corrida
/
Citocinas
/
Suplementos Nutricionais
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Interferon Cytokine Res
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos