Effect of activated charcoal on diethylcarbamazine absorption in humans.
Am J Ther
; 8(1): 7-9, 2001.
Article
em En
| MEDLINE
| ID: mdl-11304652
ABSTRACT
We investigated the effect of the oral binder-activated charcoal on the excretion of diethylcarbamazine. Six healthy volunteers were given 150 mg diethylcarbamazine with 350 mL water each. One and 2 weeks later, they received 150 mg diethylcarbamazine plus 7.5 and 15 g activated charcoal, respectively, in 350 mL water as a charcoal slurry. Urinary levels of diethylcarbamazine were measured spectrophotometrically from 1 to 72 hours after ingestion in three different periods. Treatment with activated charcoal led to 5.4% urinary recovery of diethylcarbamazine, decreased excretion rate, and a much lower plateau indicator of reduced absorption. Activated charcoal reduces the absorption and urinary excretion rate of diethylcarbamazine by adsorbing it in the gastrointestinal tract.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carvão Vegetal
/
Dietilcarbamazina
/
Filaricidas
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Ther
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Nigéria