Role of receptor editing and revision in shaping the B and T lymphocyte repertoire.
Life Sci
; 69(10): 1105-13, 2001 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-11508343
ABSTRACT
B and T lymphocytes that carry antigen receptors are able to change specificity through subsequent receptor gene rearrangements. Receptor editing and receptor revision are terms used to distinguish those rearrangements occurring, respectively, in central lymphoid organs and the periphery. Secondary rearrangement appears to be a major player at two levels in the life of B lymphocytes. First, editing preserves a diverse repertoire without compromising self-tolerance, and revision further increases this repertoire once B cells have been engaged in an immune response, most likely for a better interaction with microbes. Recent studies have likewise suggested a role for receptor editing and revision in shaping the T cell repertoire during development and tolerance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Receptores de Antígenos de Linfócitos B
/
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Rearranjo Gênico do Linfócito B
/
Rearranjo Gênico do Linfócito T
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos