Impaired detection of variable duration embedded tones in ectopic NZB/BINJ mice.
Neuroreport
; 12(13): 2875-9, 2001 Sep 17.
Article
em En
| MEDLINE
| ID: mdl-11588594
ABSTRACT
Utilizing rodent models, prior research has demonstrated a significant association between focal neocortical malformations (i.e. induced microgyria, molecular layer ectopias), which are histologically similar to those observed in human dyslexic brains, and rate-specific auditory processing deficits as seen in language impaired populations. In the current study, we found that ectopic NZB/BINJ mice exhibit significant impairments in detecting a variable duration 5.6 kHz tone embedded in a 10.5 kHz continuous background, using both acoustic reflex modification and auditory event-related potentials (AERP). The current results add further support to the association between focal cortical malformations and impaired auditory processing, and the notion that these auditory effects may occur regardless of the cortical location of the anomaly.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Percepção Auditiva
/
Transtornos da Percepção Auditiva
/
Córtex Cerebral
/
Dislexia
/
Malformações do Sistema Nervoso
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos