Calcium protects differentiating neuroblastoma cells during 50 Hz electromagnetic radiation.
Biophys J
; 81(5): 2580-9, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11606272
ABSTRACT
Despite growing concern about electromagnetic radiation, the interaction between 50- to 60-Hz fields and biological structures remains obscure. Epidemiological studies have failed to prove a significantly correlation between exposure to radiation fields and particular pathologies. We demonstrate that a 50- to 60-Hz magnetic field interacts with cell differentiation through two opposing mechanisms it antagonizes the shift in cell membrane surface charges that occur during the early phases of differentiation and it modulates hyperpolarizing K channels by increasing intracellular Ca. The simultaneous onset of both mechanisms prevents alterations in cell differentiation. We propose that cells are normally protected against electromagnetic insult. Pathologies may arise, however, if intracellular Ca regulation or K channel activation malfunctions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radiação
/
Diferenciação Celular
/
Cálcio
/
Bucladesina
/
Citoproteção
/
Potenciais da Membrana
Limite:
Animals
Idioma:
En
Revista:
Biophys J
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Itália