Sensory adaptation in naive peripheral CD4 T cells.
J Exp Med
; 194(9): 1253-61, 2001 Nov 05.
Article
em En
| MEDLINE
| ID: mdl-11696591
ABSTRACT
T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56(lck). Reduced CD5 levels in T cells deprived of pMHC contact are predictive of elevated Ca(2)+ responses to subsequent TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact may be important for regulating naive CD4 T cell responsiveness.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adaptação Fisiológica
/
Linfócitos T CD4-Positivos
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Reino Unido