FK506 suppressed the inflammatory change of EAM in SJL/J mice.
J Neurol Sci
; 193(1): 7-11, 2001 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-11718743
ABSTRACT
Experimental autoimmune myositis (EAM) is a good model of human inflammatory myopathy. We induced EAM in SJL/J mice by injection with myosin and treated inflammatory changes with FK506. The mice developed inflammatory changes after the fifth myosin injection. After treatment with FK506, inflammation was suppressed and central nuclei of the muscle fibers increased. These findings indicate that FK506 is effective in the treatment of EAM. The data suggests that FK506 inhibits interaction with calcineurin. Intercellular adhesion molecule-1 (ICAM-1) positive cells were present in the inflammatory and non-inflammatory areas of EAM. The FK506-treated group stained more weakly for ICAM-1 than the untreated EAM group.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tacrolimo
/
Músculo Esquelético
/
Doença Autoimune do Sistema Nervoso Experimental
/
Imunossupressores
/
Miosite
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Japão