ARF6: a newly appreciated player in G protein-coupled receptor desensitization.
FEBS Lett
; 521(1-3): 3-8, 2002 Jun 19.
Article
em En
| MEDLINE
| ID: mdl-12067715
ABSTRACT
The luteinizing hormone/choriogonadotropin hormone receptor (LH/CG R) signals to regulate ovulation, corpus luteum formation, and fetal survival during pregnancy. Agonist binding to the LH/CG R is poorly reversible, emphasizing the importance of a cellular mechanism to temper signaling by a potentially persistently active receptor. Like other G protein-coupled receptors (GPCRs), signaling by this receptor is modulated by its binding of an arrestin. We have identified ADP ribosylation factor 6 (ARF6) as a protein whose activation state is regulated by the LH/CG R and which functions to regulate the availability of plasma membrane-docked arrestin 2 to this receptor. We hypothesize that ARF6 might also serve GPCRs other than the LH/CG R to regulate the availability of arrestin 2 for receptor desensitization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores do LH
/
Receptores de Superfície Celular
/
Proteínas de Ligação ao GTP
/
Fatores de Ribosilação do ADP
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos