A comparison of cocaine and 'co-phenylcaine' local anaesthesia in flexible nasendoscopy.
Clin Otolaryngol Allied Sci
; 27(3): 192-6, 2002 Jun.
Article
em En
| MEDLINE
| ID: mdl-12071996
ABSTRACT
Cocaine is widely used as a local anaesthetic in the nose. However, it is potentially toxic, a known drug of addiction, and its spray delivery devices can theoretically transfer infection. This two-part study investigates a less toxic alternative, 5% lidocaine and 0.5% phenylephrine ('co-phenylcaine') solution, presented in a disposable spray. In the first part, the efficacy of co-phenylcaine was assessed in 25 healthy volunteers. Serial acoustic rhinometry showed a significant, sustained nasal decongestion after co-phenylcaine administration. Visual analogue scale (VAS) scores in response to a painful nasal stimulus confirmed a significant anaesthetic effect. In the second part, co-phenylcaine was compared with 10% cocaine spray in a randomized double-blind trial in 74 patients undergoing out-patient transnasal fibrescopic laryngoscopy. VAS pain ratings and nasal inspiratory peak flow recordings showed no difference between the two solutions. No adverse effects were noted. It is concluded that co-phenylcaine is an excellent alternative to cocaine nasal spray.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilefrina
/
Cocaína
/
Anestésicos Combinados
/
Anestesia Local
/
Anestésicos Locais
/
Lidocaína
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Otolaryngol Allied Sci
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Reino Unido