Randomized clinical trial of magnesium, diazepam, or both after out-of-hospital cardiac arrest.
Neurology
; 59(4): 506-14, 2002 Aug 27.
Article
em En
| MEDLINE
| ID: mdl-12196641
ABSTRACT
OBJECTIVE:
To evaluate the feasibility, safety, and efficacy of interventions aimed at improving neurologic outcome after cardiac arrest.METHODS:
The authors conducted a double-blind, placebo-controlled, randomized clinical trial with factorial design to see if magnesium, diazepam, or both, when given immediately following resuscitation from out-of-hospital cardiac arrest, would increase the proportion of patients awakening, defined as following commands or having comprehensible speech. If the patient regained a systolic blood pressure of at least 90 mm Hg and had not awakened, paramedics injected IV two syringes stored in a sealed kit. The first always contained either 2 g magnesium sulfate (M) or placebo (P); the second contained either 10 mg diazepam (D) or P. Awakening at any time by 3 months was determined by record review, and independence at 3 months was determined by telephone calls. Over 30 months, 300 patients were randomized in balanced blocks of 4, 75 each to MD, MP, PD, or PP. The study was conducted under waiver of consent.RESULTS:
Despite the design, the four treatment groups differed on baseline variables collected before randomization. Percent awake by 3 months for each group were MD, 29.3%; MP, 46.7%; PD, 30.7%; PP, 37.3%. Percent independent at 3 months were MD, 17.3%; MP, 34.7%; PD, 17.3%; PP, 25.3%. Significant interactions were lacking. After adjusting for baseline imbalances, none of these differences was significant, and no adverse effects were identified.CONCLUSIONS:
Neither magnesium nor diazepam significantly improved neurologic outcome from cardiac arrest.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vigília
/
Atividades Cotidianas
/
Diazepam
/
Parada Cardíaca
/
Sulfato de Magnésio
/
Doenças do Sistema Nervoso
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos