Inhibition of anaphylactic inflammation by the gp49B1 receptor on mast cells.
Mol Immunol
; 38(16-18): 1301-5, 2002 Sep.
Article
em En
| MEDLINE
| ID: mdl-12217399
ABSTRACT
gp49B1 is a member of the immunoglobulin (Ig) superfamily expressed on the surface of mast cells, macrophages, and activated natural killer cells. gp49B1 inhibits FcepsilonRI-induced activation of mast cells in vitro by virtue of two immunoreceptor, tyrosine-based inhibitory motifs that recruit the SHP-1 tyrosine phosphatase to the plasma membrane. We created gp49B1 null mice by targeted gene disruption, and found that IgE-dependent mast cell activation is augmented in these animals. Moreover, the ensuing anaphylactic reactions and inflammation are enhanced in the absence of gp49B1. Thus, gp49B1 innately counter-regulates mast cell activation mediated by Ig generated through the adaptive immune response in vivo.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Receptores Imunológicos
/
Anafilaxia
/
Mastócitos
Limite:
Animals
Idioma:
En
Revista:
Mol Immunol
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos