HbA1c as a postmortem tool to identify glycemic control.
J Forensic Sci
; 47(6): 1373-9, 2002 Nov.
Article
em En
| MEDLINE
| ID: mdl-12455667
ABSTRACT
Estimates suggest that more than 5A million U.S. citizens unknowingly have diabetes and are at increased risk of morbidity and mortality. We evaluated an immunoturbidimetric measurement of glycated hemoglobin (%HbA1c) as a postmortem tool to identify such individuals. Although postmortem samples undergo some degradation, the effects are not sufficient to invalidate the use of the test or method. Using two study populations whose medical history of diabetes was known, we found the mean %HbA1c of the non-diabetics (5.8+/-0.3) to be statistically different from that of the diabetics (12.4+/-2.8). For the population whose disease status was unknown, the %HbA1c ranged from 4.7 to 16.8. For six unknowns whose values exceeded 7.0%. the mean was 11.7%, which did not differ statistically from the diabetic mean (p = 0.6615). These studies suggest that postmortem blood samples can be used to characterize HbA1c values.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicemia
/
Hemoglobinas Glicadas
/
Diabetes Mellitus
/
Medicina Legal
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
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Aged
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Aged80
/
Female
/
Humans
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Infant
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Male
/
Middle aged
Idioma:
En
Revista:
J Forensic Sci
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos