Anti-endothelial cell reactivity, the unresolved enigma.
Int J Immunopathol Pharmacol
; 14(2): 109-118, 2001.
Article
em En
| MEDLINE
| ID: mdl-12604026
ABSTRACT
Not only are some anti-endothelial cell antibodies (AECA) directed to thus far unidentified cell membrane structures, but some ot them recognize "planted" antigens and possibly ligand-receptor complexes. The functional heterogeneity of AECA is widely acknowledged part of them activate the complement, mediate antibody-dependent cell cytotoxicity of trigger the production of tissue procoagulant factor. It has also recently been established that a proportion of AECA have the capacity to induce apoptosis of their target cells. In fact, the most direct demonstration of the pathogenicity of AECA is the autoantibody-induced murine model of vasculitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Int J Immunopathol Pharmacol
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
PATOLOGIA
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
França