[Neuroplasticity and Parkinson disease]. / Neuroplasticité et maladie de Parkinson.
Rev Neurol (Paris)
; 158 Spec no 1: S42-8, 2002 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-12690663
ABSTRACT
Emerging concept, to date, neuroplasticity becomes a concrete reality in the adult central nervous system (CNS), particularly in a so-called neurodegenerative disease as idiopathic Parkinson's disease (IPD). After a brief survey of some general aspects of plasticity in the CNS, the present tutorial review illustrates with recent data from the literature the modes of plastic changes during the course of IPD, either resulting from dopaminergic denervation (hyperactivity of remaining dopaminergic neurons with increase of their excitatory cholinergic innervation in the substantia nigra, enhancement of the corticostriatal glutamatergic synaptic activity at the striatal level) or due to dopaminergic treatment (change in phosphorylation state of the striatal glutamate receptors, internalization of D1 Dopamine receptors). Neuroplasticity in Parkinson's disease could represent a rational basis for forthcoming therapeutic issues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Plasticidade Neuronal
Limite:
Humans
Idioma:
Fr
Revista:
Rev Neurol (Paris)
Ano de publicação:
2002
Tipo de documento:
Article