Total synthesis of the reputed structure of alcyonin and reassignment of its structure.
Org Lett
; 5(9): 1543-6, 2003 May 01.
Article
em En
| MEDLINE
| ID: mdl-12713319
ABSTRACT
Introduction of the C4 hydroxyl group by an epoxy ester rearrangement is a pivotal step in the first total synthesis of the purported structure of alcyonin. As the spectral data for diol acetate 3 do not match those reported for alcyonin, the structure of this marine diterpene must be revised. Reexamination of NMR spectra, MS data, and chemical transformations of natural alcyonin suggests that the structure of this marine metabolite is allylic peroxide 15.[structure see text]
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diterpenos
/
Éteres
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos