[Screening for lung cancer with low-dose spiral CT: results in 150 asymptomatic subjects]. / Detección precoz del cáncer de pulmón por tomografía computarizada de baja dosis de radiación: resultados de una muestra de 150 individuos asintomáticos.
Med Clin (Barc)
; 121(2): 41-7, 2003 Jun 14.
Article
em Es
| MEDLINE
| ID: mdl-12828882
ABSTRACT
BACKGROUND AND OBJECTIVE:
Our aim is to present initial baseline data from a screening trial on low-dose spiral computed tomography (CT). We describe enrollment criteria and a diagnostic algorithm based on initial low-dose CT findings. SUBJECTS ANDMETHOD:
From September 2000 to May 2001, 150 asymptomatic smokers (age range 40-78 years; mean 55 years) were studied using non-enhanced low-dose spiral CT of the chest. Repeated short-term high resolution CT follow-up was performed for non-calcified pulmonary nodules smaller than 10 mm in diameter. Non-calcified pulmonary nodules 10 mm or larger were considered as potentially malignant and a complementary positron emission tomography (PET) exam was recommended.RESULTS:
54 non-calcified pulmonary nodules were found in 34 out of 141 (24.15%) symptom-free subjects. The diameter was 5 mm or shorter in 24 participants (70.6%), 6-10 mm in 7 (20.6%) and longer than 10 mm in 3 (8.8%) individuals. One patient with a non-calcified pulmonary nodule of at least 10 mm underwent a complementary PET exam, which was positive. Biopsy of this nodule demonstrated lung cancer (squamous cell carcinoma). CT follow-up over one year was decided in the other two subjects having non-calcified pulmonary nodules longer than 10 mm, as no radiographic signs indicative of malignancy were observed in the baseline scan.CONCLUSION:
Following this low-dose CT based screening programme, detection of early-stage lung cancer in asymptomatic subjects at high risk of developing the disease is feasible. Further studies are however necessary to pursue more definitive results.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma Broncogênico
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Nódulo Pulmonar Solitário
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Neoplasias Pulmonares
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Screening_studies
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
Es
Revista:
Med Clin (Barc)
Ano de publicação:
2003
Tipo de documento:
Article