Inhibitory and excitatory mechanisms underlying auditory responses to learned vocalizations in the songbird nucleus HVC.
Neuron
; 39(1): 177-94, 2003 Jul 03.
Article
em En
| MEDLINE
| ID: mdl-12848941
ABSTRACT
Speech and birdsong require auditory feedback for their development and maintenance, necessitating precise auditory encoding of vocal sounds. In songbirds, the telencephalic song premotor nucleus HVC contains neurons that respond highly selectively to the bird's own song (BOS), a property distinguishing HVC from its auditory afferents. We examined the contribution of inhibitory and excitatory synaptic inputs to BOS-evoked firing in those HVC neurons innervating a pathway essential for audition-dependent vocal plasticity. Using in vivo intracellular techniques, we found that G protein-coupled, potassium-mediated inhibition, tuned to the BOS, interacts with BOS-tuned excitation through several mechanisms to shape neuronal firing patterns. Furthermore, in the absence of this inhibition, the response bias to the BOS increases, reminiscent of cancellation mechanisms in other sensorimotor systems.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Auditivo
/
Vocalização Animal
/
Estimulação Acústica
/
Aves Canoras
/
Canais de Potássio Corretores do Fluxo de Internalização
/
Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Revista:
Neuron
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos