Age and beta-adrenergic receptor sensitivity to S(-)- and R,S(+/-)-propranolol in humans.
Clin Pharmacol Ther
; 51(5): 549-54, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1316824
ABSTRACT
The relationship between age and beta-adrenergic receptor sensitivity to the pharmacologically active S(-) enantiomer and the racemic mixture of propranolol was evaluated in 46 healthy male subjects (age range, 24 to 89 years). The in vivo apparent dissociation constants for S(-)- and R,S(+/-)-propranolol were determined on the basis of the unbound steady-state plasma concentration of each and the dose of isoproterenol needed to increase the heart rate of the subjects by 25 beats/min in the absence (I25) and then in the presence of a continuous propranolol infusion. The I25 was significantly correlated with age (r = 0.700, p less than 0.05). The apparent dissociation constant for S(-)- and R,S(+/-)-propranolol demonstrated a significant, although weak, increase with advancing age (r = 0.403 and r = 0.396, respectively; p less than 0.05). Although these findings confirm those of other studies, beta-receptor sensitivity to propranolol was only modestly decreased with age in this study.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propranolol
/
Receptores Adrenérgicos beta
/
Frequência Cardíaca
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
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Aged
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Aged80
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
1992
Tipo de documento:
Article