Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase.
Science
; 257(5077): 1685-9, 1992 Sep 18.
Article
em En
| MEDLINE
| ID: mdl-1382315
ABSTRACT
The double-stranded RNA-dependent protein kinase (dsRNA-PK) is thought to be a key mediator of the antiviral and antiproliferative effects of interferons (IFNs). Studies examining the physiological function of the kinase suggest that it participates in cell growth and differentiation by regulating protein synthesis. Autophosphorylation and consequent activation of dsRNA-PK in vitro and in vivo result in phosphorylation of the alpha subunit of eukaryotic initiation factor-2 (eIF-2) and inhibition of protein synthesis. Expression of a functionally defective mutant of human dsRNA-PK in NIH 3T3 cells resulted in malignant transformation, suggesting that dsRNA-PK may function as a suppressor of cell proliferation and tumorigenesis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Transformação Celular Neoplásica
/
Interferons
/
Mutação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Canadá