Cyclophosphamide-induced suppressor cells in nude mice.
Anticancer Drugs
; 3(4): 427-33, 1992 Aug.
Article
em En
| MEDLINE
| ID: mdl-1421440
ABSTRACT
Lymphocytes regenerated after treatment with a high dose of cyclophosphamide (CY) were characterized in nude mice. Ten days after a single injection of 200 mg/kg CY into nude mice, regenerated spleen cells suppressed in vitro primary and second antibody production against sheep red blood cells. The CY-treated spleen cells exhibited normal natural killer (NK) activity, very low B and T cell content, but increases in cell surface charge [electrophoretic mobility (EPM)] and histamine receptors. The suppressor cells could not be removed by treatment with anti-Thy-1 plus complement (C), or treatment with antiasialo GM1 (aGM1) plus C, which abrogated NK activity. It was concluded that CY-treated spleen cells, which exhibited high EPM and histamine receptors, comprise the natural suppressor cells which are Ig-, Thy-1- and aGM-1.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Histamínicos
/
Linfócitos T Reguladores
/
Ciclofosfamida
/
Eritrócitos
/
Antígenos de Superfície
Limite:
Animals
Idioma:
En
Revista:
Anticancer Drugs
Assunto da revista:
ANTINEOPLASICOS
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Japão