Inhibition of human immunodeficiency virus reverse transcriptase by synadenol triphosphate and its E-isomer.
J Med Chem
; 46(22): 4799-802, 2003 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-14561099
ABSTRACT
Triphosphate 1c is a potent competitive inhibitor of wild-type HIV-1 reverse transcriptase with K(i) close to ddATP. The E-isomer 2c is about 30-times weaker. Triphosphates 1c and 2c interact with the same active site of reverse transcriptase as ddATP. The extent of inhibition of two mutant forms of reverse transcriptase (RT), RT(M184V) and RT(M184I), with triphosphate 1c was about 5 and 8 times lower than that of wild-type RT(wt).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Transcriptase Reversa
/
Fármacos Anti-HIV
/
Transcriptase Reversa do HIV
/
Nucleosídeos
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos