Heterocyclic aminopyrrolidine derivatives as melatoninergic agents.
Bioorg Med Chem Lett
; 13(24): 4381-4, 2003 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-14643330
ABSTRACT
A series of chiral heterocyclic aminopyrrolidine derivatives was synthesized as novel melatoninergic ligands. Binding affinity assays were performed on cloned human MT(1) and MT(2) receptors, stably expressed in NIH3T3 cells. Compound 16 was identified as an orally bioavailable agonist at MT(1) and MT(2) melatonin receptors with low vasoconstrictive activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminoquinolinas
/
Compostos Heterocíclicos
/
Melatonina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos