Micromide and guamamide: cytotoxic alkaloids from a species of the marine cyanobacterium Symploca.
J Nat Prod
; 67(1): 49-53, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14738385
ABSTRACT
Two new cytotoxins have been isolated from a species of marine cyanobacterium belonging to the genus Symploca that was collected in Guam. These new compounds, micromide (1) and guamamide (2), were accompanied by the known lipopeptides apramides A (3), B (4), and G (5). The planar structures of both alkaloids were elucidated by standard 2D NMR techniques, and the configurations of the amino acid-derived units in 1 were determined by chiral HPLC. The stereochemistry of the beta-methoxyhexanoic acid in 1 was determined by derivatization with methyl d-mandelate, after acid hydrolysis, and comparison with synthetic standards.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Cianobactérias
/
Alcaloides
/
Lipoproteínas
Limite:
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2004
Tipo de documento:
Article
País de afiliação:
Estados Unidos