Acremonidins, new polyketide-derived antibiotics produced by Acremonium sp., LL-Cyan 416.
J Antibiot (Tokyo)
; 56(11): 923-30, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14763558
ABSTRACT
Acremonidins A to approximately E (1 to approximately 5) were produced by fermentation of Acremonium sp., LL-Cyan 416, in heterogeneous phases. The structures of these compounds, containing a bridging keto group, were determined by spectroscopic analysis. Acremonidins A and B showed moderate activity against Gram-positive bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci. Selective acylations of acremonidin B afforded ester derivatives 6 to approximately 9 that exhibited improved antibacterial activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antibacterianos
Idioma:
En
Revista:
J Antibiot (Tokyo)
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos