Ameliorative effects of black tea extract on aflatoxin-induced lipid peroxidation in the liver of mice.
Food Chem Toxicol
; 43(1): 99-104, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15582201
ABSTRACT
We have evaluated the ameliorative effect of black tea extract on aflatoxin-induced lipid peroxidation in the liver of mice. Adult male albino mice were orally administered with 25 and 50 microg of aflatoxin in 0.2 ml olive oil/animal/day for 30 days. Results revealed dose-dependent and significantly (p<0.05) higher lipid peroxidation in the liver of aflatoxin-treated mice than that of vehicle control. As compared with vehicle control, the levels of non-enzymatic antioxidants such as glutathione and ascorbic acid, as well as the enzymatic antioxidants such as superoxide dismutase, glutathione peroxidase and catalase were significantly (p<0.05) lowered in the liver of aflatoxin-treated mice. Oral administration of two percent aqueous black tea extract along with aflatoxin for 30 days (groups 6 and 7) caused significant (p<0.05) amelioration in aflatoxin-induced lipid peroxidation by increasing significantly (p<0.05) the activities of enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and contents of non-enzymatic (glutathione and ascorbic acid) antioxidants in the liver of mice as compared with those given aflatoxin alone (groups 4 and 5). Thus, oral administration of black tea along with aflatoxin significantly (p<0.05) ameliorates aflatoxin-induced lipid peroxidation in the liver of mice.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Chá
/
Extratos Vegetais
/
Peroxidação de Lipídeos
/
Aflatoxinas
/
Fígado
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Food Chem Toxicol
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Índia