Phenotypic and genotypic characterization of macrolide resistant Streptococcus pneumoniae recovered from adult patients with community-acquired pneumonia in an Argentinian teaching hospital.
Int J Antimicrob Agents
; 25(3): 260-3, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15737523
ABSTRACT
Streptococcus pneumoniae isolates (n = 262) were recovered from adult patients with community-acquired pneumonia. Erythromycin-resistance levels increased from 9% (1997-1998) to 16% (2000-2002). Sampling for resistance mechanisms prevalent within 19 erythromycin-resistant S. pneumoniae showed mef(E) in 13/19 isolates while 4/19 carried the erm(B) gene (3/19 cMLS(B) and 1/19 iMLS(B) phenotype). MIC ranges for erythromycin and clindamycin were 0.5-16 mg/l and <0.008-0.063 mg/l for the M phenotype, 128-512 mg/l and 128-256 mg/l for the cMLS(B) phenotype, and 4 and <0.008 mg/l for the iMLS(B) phenotype. This is the first report studying the prevalence of macrolide resistance determinants in S. pneumoniae in our country.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumonia Pneumocócica
/
Streptococcus pneumoniae
/
Infecções Comunitárias Adquiridas
/
Macrolídeos
/
Farmacorresistência Bacteriana
/
Antibacterianos
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Humans
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Int J Antimicrob Agents
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Argentina