Neuronal specific regulatory elements in apolipoprotein E gene proximal promoter.
Neuroreport
; 16(9): 1027-30, 2005 Jun 21.
Article
em En
| MEDLINE
| ID: mdl-15931082
ABSTRACT
Systemic and local changes in apolipoprotein E (ApoE) quantity have been related with Alzheimer's and other neurodegenerative diseases, showing the relevance of maintaining physiological ApoE levels. However, APOE transcription has not been extensively studied in neural cells. In this report, we study the transcriptional activity of different APOE proximal promoter regions and their binding to nuclear proteins from human neural (astrocytoma and neuroblastoma) and peripheral (hepatoma and lymphoma) cell lines. We define several regions with a negative regulatory effect in all the cells and a region with a strong positive activity in neuroblastoma cells. Additionally, we show that the -219T/G polymorphism produces variations in APOE transcriptional activity, with the G allele showing higher activity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apolipoproteínas E
/
Sequências Reguladoras de Ácido Nucleico
/
Regulação da Expressão Gênica
/
Regiões Promotoras Genéticas
/
Neurônios
Limite:
Humans
Idioma:
En
Revista:
Neuroreport
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Espanha