Dimerization of chemokine receptors and its functional consequences.
Cytokine Growth Factor Rev
; 16(6): 611-23, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-15979374
ABSTRACT
It became clear over the recent years that most, if not all, G protein-coupled receptors (GPCR) are able to form dimers or higher order oligomers. Chemokine receptors make no exception to this new rule and both homo- and heterodimerization were demonstrated for CC and CXC receptors. Functional analyses demonstrated negative binding cooperativity between the two subunits of a dimer. The consequence is that only one chemokine can bind with high affinity onto a receptor dimer. In the context of receptor activation, this implies that the motions of helical domains triggered by the binding of agonists induce correlated changes in the other protomer. The impact of the chemokine dimerization process in terms of co-receptor function and drug development is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores de Quimiocinas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cytokine Growth Factor Rev
Assunto da revista:
ALERGIA E IMUNOLOGIA
/
BIOQUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Bélgica