Increased white matter hyperintensities in male methamphetamine abusers.
Drug Alcohol Depend
; 81(1): 83-8, 2006 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-16005161
ABSTRACT
BACKGROUND:
The current study was conducted to compare the prevalence, severity, and location of white matter signal hyperintensities (WMH) on brain magnetic resonance (MR) imaging in methamphetamine (MA) abusers.METHODS:
Thirty-three MA abusers and 32 age- and gender-matched healthy comparison subjects were studied. Axial T-2 weighted images and fluid attenuated inversion recovery axial images were obtained using 3.0 T MR scanner. The severity of WMH was assessed separately for deep and periventricular WMH. Ordinal logistic regression models were used to assess the odds ratio for WMH.RESULTS:
MA abusers had greater severity of WMH than the healthy comparison subjects (odds ratio 7.06, 8.46, and 4.56 for all, deep, and periventricular WMH, respectively). Severity of deep WMH correlated with total cumulative dose of MA (p = 0.027). Male MA abusers had greater severity of WMH than female MA abusers (odds ratio = 10.00). While male MA abusers had greater severity of WMH than male comparison subjects (odds ratio = 18.86), there was no significant difference in WMH severity between female MA abusers and female comparison subjects.CONCLUSIONS:
The current study reports increased WMH in MA abusers, which may be related to MA-induced cerebral perfusion deficits. In addition, female MA abusers had less severe WMH than male MA abusers, possibly due to estrogen's protective effect against ischemic or neurotoxic effects of MA.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imageamento por Ressonância Magnética
/
Demência Vascular
/
Doenças Desmielinizantes
/
Transtornos Relacionados ao Uso de Anfetaminas
/
Síndromes Neurotóxicas
/
Metanfetamina
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
País/Região como assunto:
Asia
Idioma:
En
Revista:
Drug Alcohol Depend
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Coréia do Sul