Comparative pharmacokinetics of lovastatin, simvastatin and pravastatin in humans.
J Clin Pharmacol
; 32(2): 136-40, 1992 Feb.
Article
em En
| MEDLINE
| ID: mdl-1613123
ABSTRACT
Twelve healthy male volunteers received single market-image 40-mg oral doses of lovastatin and simvastatin (both lactone prodrugs), or pravastatin (a beta-hydroxyacid) at 1 week intervals in a three-way crossover study to quantify HMG-CoA reductase inhibitors in plasma. Multiple plasma samples were collected up to 24 hours after the dose and assayed for active and total HMG-CoA reductase inhibitors. After equal oral doses, higher plasma concentrations of HMG-CoA reductase inhibitory activity after pravastatin than after either lovastatin of simvastatin (2-3 fold greater area under the concentration-time curve) suggest a greater potential availability of pravastatin-related inhibitory activity to peripheral tissues.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lovastatina
/
Pravastatina
/
Inibidores de Hidroximetilglutaril-CoA Redutases
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Pharmacol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Finlândia