Further extension of mammalian GATA-6.
Dev Growth Differ
; 47(9): 591-600, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16316404
ABSTRACT
Mammalian GATA-6, which has conserved tandem zinc fingers (CVNC-X(17)-CNAC)-X(29)-(CXNC-X(17)-CNAC), is essential for the development and specific gene regulation of the heart, gastrointestinal tract and other tissues. GATA-6 recognizes the (A/T/C)GAT(A/T)(A) sequence, and interacts with other transcriptional regulators through its zinc-finger region. The mRNA of GATA-6 uses two Met codons in frame as translational initiation codons, and produces L- and S-type GATA-6 through leaky ribosome scanning. GATA-6 is subjected to cAMP-dependent proteolysis by a proteasome in a heterologous expression system. These protein-based characteristics of GATA-6 will be helpful for the identification of target genes, together with determination of the in vivo binding sites for GATA-6 and understanding of the complex network of gene regulation mediated by GATA-6.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Transcrição GATA6
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Dev Growth Differ
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Japão