Regulation of theta-antigen expression by agents altering cyclic AMP level and by thymic factor.
Ann N Y Acad Sci
; 249: 316-27, 1975 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-165766
ABSTRACT
Thymic factor, cyclic AMP, and products increasing its cellular level, such as Prostaglandin E1, induce the appearance of the theta-antigen on T-cell precursors whether assessed by a rossette-inhibition assay or a cytotoxic assay after cell fractionation on BSA discontinuous gradiet. Synergism has been demonstrated between cyclic AMPT and TF for that effect. Conversely, decrease of theta expression has been obtained by altering cyclic AMP level in theta-positive cells either increasing it by dibutyryl cAMP treatment or decreasing it by indomethacin treatment. Finally, these data suggest the involvement of cyclic AMP in the regulation of theta expression under thymic hormone control.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Timosina
/
Extratos do Timo
/
Linfócitos
/
AMP Cíclico
/
Isoantígenos
Limite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Ano de publicação:
1975
Tipo de documento:
Article