Ca2+ channel activating action of maitotoxin in cultured brainstem neurons.
Eur J Pharmacol
; 536(3): 223-31, 2006 May 01.
Article
em En
| MEDLINE
| ID: mdl-16581067
ABSTRACT
The actions of maitotoxin were studied using cultured brainstem cells and adrenal chromaffin cells. Maitotoxin induced a profound increase in the Ca2+ influx into cultured brainstem cells after a brief lag period. The maitotoxin-induced Ca2+ influx was suppressed by various voltage-dependent Ca2+ channel blockers such as Co2+, Mn2+, verapamil and diltiazem. Maitotoxin-catecholamine release in brainstem cells initiated to increase after a lag period of about 1 min and the increase continued even at 4 min after treatment, while in the adrenal chromaffin cells the release started after an about 1-min lag period to attain a maximum within first 2-min and gradually decrease thereafter. These results suggest that maitotoxin acts on Ca2+ channels to increase the Ca2+ influx, accompanied by enhancement of catecholamine release in the brainstem cells with a different temporal profile from that in the adrenal chromaffin cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Canais de Cálcio
/
Cálcio
/
Oxocinas
/
Toxinas Marinhas
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Japão