8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs).
Bioorg Med Chem
; 14(16): 5446-50, 2006 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-16730996
ABSTRACT
A series of 8-hydroxyquinoline derivatives with different substituted groups at 2- or 5-position have been synthesized and characterized. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSCs) have been evaluated by MTT assay and flow cytometry. We also analyzed the ability of these compounds to regulate the proliferation of rMSCs and the relationship with the structures of 8-hydroxyquinoline. Compounds 8-11, in which, the vinyl-substituents are on the 2-position of 8-hydroxyquinoline, appear to be able to induce the proliferation of rMSCs. These results show that compounds 8-11 provide a kind of new substances for regulating the proliferation of rMSCs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células da Medula Óssea
/
Oxiquinolina
/
Proliferação de Células
/
Células-Tronco Mesenquimais
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
China