Clonidine in horses: identification, detection, and clinical pharmacology.
Vet Ther
; 7(2): 141-55, 2006.
Article
em En
| MEDLINE
| ID: mdl-16871496
ABSTRACT
Clonidine is classified as a class 3 performance-enhancing agent by the Association of Racing Commissioners International and thus has the potential to influence the outcome of a race. In this study, the authors developed and validated a sensitive gas chromatograph and mass spectrometer method to determine the pharmacokinetic parameters of clonidine in equine plasma samples after IV administration of a single dose (0.025 mg/kg) of clonidine in horses. At this dose, clonidine produced rapid and profound sedation, which cold be quickly reversed with yohimbine. Clonidine was able to produce an analgesic effect but failed to provide maximal analgesia in all horses; the limited analgesic effect persisted for about 60 minutes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Clonidina
/
Agonistas alfa-Adrenérgicos
/
Cavalos
/
Analgésicos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Vet Ther
Assunto da revista:
MEDICINA VETERINARIA
/
TERAPEUTICA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos