Radiation-induced effects on gene expression: an in vivo study on breast cancer.
Radiother Oncol
; 80(2): 230-5, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16890317
ABSTRACT
BACKGROUND AND PURPOSE:
Breast cancer is diagnosed worldwide in approximately one million women annually and radiation therapy is an integral part of treatment. The purpose of this study was to investigate the molecular basis underlying response to radiotherapy in breast cancer tissue. MATERIAL ANDMETHODS:
Tumour biopsies were sampled before radiation and after 10 treatments (of 2 Gray (Gy) each) from 19 patients with breast cancer receiving radiation therapy. Gene expression microarray analyses were performed to identify in vivo radiation-responsive genes in tumours from patients diagnosed with breast cancer. The mutation status of the TP53 gene was determined by using direct sequencing. RESULTS ANDCONCLUSION:
Several genes involved in cell cycle regulation and DNA repair were found to be significantly induced by radiation treatment. Mutations were found in the TP53 gene in 39% of the tumours and the gene expression profiles observed seemed to be influenced by the TP53 mutation status.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Genes p53
/
Proteína Supressora de Tumor p53
Limite:
Female
/
Humans
Idioma:
En
Revista:
Radiother Oncol
Ano de publicação:
2006
Tipo de documento:
Article