Persistent infection with and serologic cross-reactivity of three novel murine noroviruses.
Comp Med
; 56(4): 247-51, 2006 Aug.
Article
em En
| MEDLINE
| ID: mdl-16941951
ABSTRACT
According to serologic testing, murine norovirus is the most prevalent viral pathogen in contemporary laboratory mice. Previously, murine norovirus 1 (MNV-1) was the only norovirus reported to infect research mice. In this study, 3 novel murine norovirus strains--MNV-2, MNV-3, and MNV-4--were isolated from geographically separate mouse research colonies. All 4 murine norovirus strains used as individual antigens in microsphere fluorescent immunoassays displayed serologic cross-reactivity to serum from mice inoculated with MNV-1, MNV-2, MNV-3, or MNV-4. In addition, reverse transcriptase-polymerase chain reaction analysis at 8 wk postinoculation detected virus in the feces and tissues of all mice experimentally inoculated with MNV-2, MNV-3, or MNV-4. This finding suggests that mice can have prolonged fecal shedding of and can become persistently infected with murine noroviruses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças dos Roedores
/
Infecções por Caliciviridae
/
Reações Cruzadas
/
Norovirus
Tipo de estudo:
Etiology_studies
Limite:
Animals
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Comp Med
Assunto da revista:
MEDICINA
/
MEDICINA VETERINARIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos