Analysis of reports of human exposure to Micotil 300 (tilmicosin injection).
J Am Vet Med Assoc
; 229(11): 1737-42, 2006 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-17144818
ABSTRACT
OBJECTIVE:
To identify clinical signs associated with and outcome of human exposure to Micotil 300 (tilmicosin injection).DESIGN:
Retrospective case series. STUDY POPULATION Reports of 3,168 human exposures to Micotil 300. PROCEDURES Reports of human exposure to Micotil 300 submitted to the Elanco Animal Health Pharmacovigilance Unit between March 1992 and March 2005 were reviewed.RESULTS:
At least 1 clinical sign was described in 1,404 (44%) reports, whereas the remaining 1,764 (56%) exposures were presumably asymptomatic. Eighty percent of exposures involved males; mean age was 38 years. Sixty-one percent of exposures were a result of accidental injection, with injection site pain, bleeding, swelling, or inflammation being the most common signs, followed by nausea, tachycardia, dizziness, anxiety, an abnormal taste, headache, lightheadedness, limb pain, paresthesia, chest pain, and soreness. Only 156 (5%) reports involved serious adverse effects (ie, tachycardia, bradycardia, hypertension, hypotension, heart disorder, chest pain, tachypnea, or death). There were reports of 13 deaths following tilmicosin exposure, but only 2 of those deaths were related to accidental exposure. Time to onset of clinical signs was < or = 60 minutes in 63 of the 156 (40%) reports involving serious adverse effects. CONCLUSIONS AND CLINICAL RELEVANCE Results suggest that the overall risk of accidental human exposure to tilmicosin resulting in serious adverse effects is low (approx 2 people for every 1 million doses administered). Nevertheless, safe handling and proper use should be emphasized.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Acidentes de Trabalho
/
Tilosina
/
Exposição Ocupacional
/
Ferimentos Penetrantes Produzidos por Agulha
/
Macrolídeos
/
Drogas Veterinárias
/
Antibacterianos
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
J Am Vet Med Assoc
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos