Leucocyte depletion in a drowning victim during rewarming with extracorporeal circulation may limit pulmonary oedema.
Perfusion
; 21(5): 305-8, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-17201086
ABSTRACT
INTRODUCTION:
We report two drowning victims with hypothermic circulatory arrest who were resuscitated with the use of extracorporeal circulation (ECC). The first patient developed severe post-bypass pulmonary oedema and inspired us to use a leucocyte-depletion filter in the second patient to attenuate leucocyte-mediated pulmonary reperfusion injury.METHODS:
In the first patient, a standard extracorporeal circuit was used. In the second patient, systemic leucocyte depletion was applied using leucocyte-depletion filters (Pall RS 1, Pall, Portsmouth, UK), in the venous side of the extracorporeal circuit. Circulating leucocyte counts were measured and arterial blood gas analysis and chest X-rays were performed.RESULTS:
Both patients showed a decrease of the circulating leucocyte counts during rewarming and had nearly similar leucocyte counts on arrival at the intensive care unit (ICU). The first patient developed severe pulmonary oedema, with poor arterial blood gases, whereas the second patient, who had leucocyte-depletion by filtration, did not develop severe pulmonary oedema, and had good arterial blood gases.CONCLUSION:
Profound leucocyte-depletion by means of filtration may have contributed to limit leucocyte-mediated pulmonary reperfusion injury.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Edema Pulmonar
/
Traumatismo por Reperfusão
/
Afogamento Iminente
/
Reaquecimento
/
Procedimentos de Redução de Leucócitos
/
Circulação Extracorpórea
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Child, preschool
/
Humans
/
Male
Idioma:
En
Revista:
Perfusion
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Holanda