Biological properties of a renotropic protein present in plasma of uninephrectomized rats.
Ren Physiol Biochem
; 14(6): 224-35, 1991.
Article
em En
| MEDLINE
| ID: mdl-1720253
ABSTRACT
The biological characteristics of a kidney growth factor (KGF) from uninephrectomized rat plasma have been studied. A crude preparation of this factor [Nephrol. Dial. Transplant. 4 334-338, 1989] was further purified by hydrophobic interaction HPLC and gel filtration. KGF was found to be a heat- and trypsin-resistant protein. This factor stimulated dose-dependently DNA synthesis by the mouse kidney in vivo, and by either rat renal tubules or serum-deprived LLC-PK1 cells, in vitro. KGF also increased protein synthesis in these cells, in a dose-dependent manner. Moreover, KGF stimulated sodium uptake by these cells, associated with the maximal increase of protein synthesis. Our findings indicate that KGF is a potent renotropic protein which can play a key role in the renal compensatory growth after uninephrectomy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Substâncias de Crescimento
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Rim
Limite:
Animals
Idioma:
En
Revista:
Ren Physiol Biochem
Assunto da revista:
NEFROLOGIA
Ano de publicação:
1991
Tipo de documento:
Article